HCG Pregnyl 1500iu

Manufacturer: Organon, Turkey

Pharmaceutical name: Human Chorionic Gonadotropin

Pack: 1 kit (1500 iu amp and solution)

A single kit of Pregnyl contains lyophilized powder intended for injection and a solvent for its reconstitution.

 

HCG Pregnyl 1500iu is not classified as an anabolic or androgenic steroid; rather, it is a natural protein hormone produced in the placenta of a pregnant woman. HCG is generated in the placenta shortly after implantation has occurred. It has luteinizing properties due to its close similarity to the luteinizing hormone (LH) produced by the anterior pituitary gland. In the early weeks of pregnancy, specifically the first 6-8 weeks, the HCG that forms supports the ongoing production of estrogens and gestagens from the corpus luteum. Subsequently, the placenta itself starts to produce these two hormones.

 

HCG is derived from the urine of pregnant women, as it is excreted unchanged from the bloodstream through the kidneys into urine. The commercial version of HCG is available as a dry powder and can be used by both men and women. In women, HCG injections can induce ovulation by influencing the later stages of ovum development, thereby promoting ovulation. It also aids in the production of estrogens and corpus luteum. The similarity of exogenous HCG to luteinizing hormone (LH), which is produced by the pituitary gland, makes it particularly appealing to athletes. In men, LH acts on Leydig cells in the testes, stimulating the production of androgenic hormones like testosterone. Consequently, athletes often use injectable HCG to boost testosterone production.

 

HCG Pregnyl 1500iu is frequently used alongside anabolic/androgenic steroids during or following treatment. As previously mentioned, the use of oral and injectable steroids can lead to negative feedback after a certain level and duration, signaling the hypothalamic-pituitary-gonadal axis due to misleading cues sent to the hypothalamus by the steroids. The hypothalamus then instructs the pituitary gland to decrease or cease the production of FSH (follicle-stimulating hormone) and LH. As a result, testosterone production diminishes because the Leydig cells in the testes, under-stimulated by decreased LH, are unable to produce sufficient testosterone. Since it generally takes the body time to resume its natural testosterone production, athletes may experience a challenging transition period following the cessation of steroids, often resulting in significant losses in strength and muscle mass. Administering HCG post-steroid treatment can mitigate these effects by rapidly and reliably increasing testosterone production in the testes. In cases of testicular atrophy caused by high doses and prolonged use, HCG can quickly restore testicular size.

 

Due to the ability of occasional HCG injections during steroid cycles to prevent testicular atrophy, many athletes opt to use HCG for two to three weeks midway through their steroid treatment. It is commonly reported that during this period, athletes often see significant improvements in both strength and muscle mass. This can be attributed to two main factors: the immediate spike in the athlete's own testosterone levels from HCG and the heightened concentration of anabolic substances in the bloodstream induced by steroids. Many bodybuilders, powerlifters, and weightlifters have noted a decrease in libido at the end of an intense training cycle, just before or after competitions, and particularly towards the conclusion of steroid treatment. Athletes with past steroid use typically accept this as a temporary condition, but those continuously using steroids might face psychological impacts or relationship issues as a result, which should be carefully considered when administering HCG at regular intervals. Reduced libido and spermatogenesis due to steroids can often be successfully addressed with HCG treatment.

 

Most athletes, however, prefer to use HCG Pregnyl 1500iu at the end of their cycles to avoid a "crash," facilitating a smooth transition back into "natural training." An important condition for this is that the dosage of steroids should be gradually reduced prior to initiating HCG treatment. While HCG leads to a quick and substantial rise in endogenous plasma testosterone levels, it does not completely prevent the loss of strength and mass that often accompanies the conclusion of steroid utilization. Athletes may still face a delayed adjustment period, as has frequently been noted. Although HCG stimulates endogenous testosterone production, it does not restore the normal functioning of the hypothalamic/pituitary-testicular axis. The hypothalamus and pituitary may continue to remain in a refractory state following prolonged steroid usage even while using HCG, as the endogenous testosterone produced from HCG suppresses natural LH production. After stopping HCG, the athlete still needs to undergo a readjustment period, which is merely postponed by the prior use of HCG. Therefore, experienced athletes often follow HCG treatment with Clomid or Clenbuterol or may commence another cycle of steroids immediately. Some choose to use HCG simply to take a break from steroids for a period of two to three weeks.

 

Unfortunately, many bodybuilders still believe that HCG aids in achieving a harder physique when preparing for competition by promoting the breakdown of subcutaneous fat, thus enhancing muscle definition and vascularity. However, the HCG package insert clearly states that there is no known impact on fat metabolism, appetite, hunger sensation, or body fat distribution. HCG has not been shown to be an effective adjunct therapy in the treatment of obesity and does not enhance fat loss beyond what is achieved through caloric restriction.

 

Athletes are advised to inject 5000 IU every five days. Since testosterone levels remain significantly elevated for several days, more frequent HCG injections are unnecessary. The appropriate dosage varies for each athlete and should be determined according to the length of previous steroid use and the potency of the steroid compounds. Athletes who have used steroids for over three months or those taking highly androgenic steroids such as Androlic, Sustanon 250, Cypionate, or Dianabol (D-bol) should consider higher dosages. Generally, an effective dosage ranges from 2000 to 5000 IU per injection, administered every five days, with HCG usage limited to a maximum of four weeks.

 

If male athletes use HCG in high dosages over extended periods, there is a risk that the testes may eventually respond poorly to subsequent HCG administration and natural LH release, potentially leading to long-term gonadal dysfunction. It is recommended to limit HCG cycles to around three weeks at a time, with a pause of at least one month in between cycles. For example, one might use HCG for two or three weeks during a cycle and again for two or three weeks at the end. Prolonged HCG use is speculated to possibly repress the body’s natural gonadotropin production indefinitely, which is why short cycles are typically favored.

 

HCG Pregnyl 1500iu can lead to side effects similar to those associated with injectable testosterone. An increase in testosterone production may also raise estrogen levels, leading to conditions such as gynecomastia, which could result in temporary breast enlargement or an exacerbation of existing breast tissue in men. To mitigate this, discerning athletes often combine HCG with anti-estrogens. Male users also often report heightened libido and increased frequency of erections. At higher doses, HCG may induce acne vulgaris and water retention, which is particularly notable since this can cause muscles to appear swollen and less defined. Athletes who have previously elevated their endogenous testosterone levels using Clomid and who then take HCG could experience significant water retention and pronounced feminization symptoms (such as gynecomastia and fat distribution in the hips), due to the high testosterone conversion rates to estrogens. In younger athletes, HCG, like anabolic steroids, poses a risk of premature closure of growth plates, leading to stunted growth. Other possible adverse effects may include mood swings and high blood pressure. HCG Pregnyl 1500iu is also used as a "bridge" for doping purposes before competitions that may involve drug testing.

 

The method of administering HCG is also somewhat unique. Choriongonadotropin is available as a freeze-dried white powder, typically used in a compressed form. Due to its low structural stability, it can easily disintegrate, creating the appearance of a reduced volume; however, this does not affect its efficacy or quantity. Each HCG package comes with another vial of an isotonic sodium chloride solution. After both vials are opened in a sterile manner, the liquid should be injected into the HCG vial and mixed with the powder. This solution is ready for intramuscular injection. If any solution remains after injection, it should be refrigerated. There is no need to refrigerate the unmixed HCG, but it should be stored away from light and kept below 25°C. HCG is considered a relatively expensive substance.